Product Name :
2-Methylthioadenosine 5′-monophosphate triethylammonium salt (CAS 22140-20-1 (non-salt))
Synonym :
2-MeSAMP
Application :
2-Methylthioadenosine 5′-monophosphate triethylammonium salt is a P2Y(AC) antagonist
CAS:
22140-20-1 (non-salt)
Purity:
Molecular Weight:
393.31 (anhydrous free acid basis)
Formula :
C11H16N5O7PS•xC6H15N
Physical state:
Solid
solubility :
Shipping Condition :
Desiccate at -20° C
Melting point:
95° C
SMILES:
CCN(CC)CC.CSC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O.O
References:
:Distinct roles for Rap1b protein in platelet secretion and integrin alpha IIb beta 3 outside-in signaling. | Zhang, G., et al. 2011. J Biol Chem. 286: 39466-77. PMID: 21940635Short-acting P2Y12 blockade to reduce platelet dysfunction and coagulopathy during experimental extracorporeal circulation and hypothermia. | Krajewski, S., et al. 2012. Br J Anaesth. 108: 912-21. PMID: 22369765Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intraluminal thrombus contraction. | Muthard, RW. and Diamond, SL. 2012. Arterioscler Thromb Vasc Biol. 32: 2938-45. PMID: 23087356The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism. | Xiang, B., et al. 2012. PLoS One. 7: e51037. PMID: 23236426Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets. | Arachiche, A., et al. 2013. PLoS One. 8: e55740. PMID: 23405206Detection of platelet sensitivity to inhibitors of COX-1, P2Y, and P2Y using a whole blood microfluidic flow assay. | Li, R. and Diamond, SL. 2014. Thromb Res. 133: 203-10. PMID: 24365044Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis. | Tourdot, BE., et al. 2014. Arterioscler Thromb Vasc Biol. 34: 2644-50. PMID: 25278289Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.Formula of DBCO-acid | Cooke, NM.2-Bromo-N,N-diphenylaniline Order , et al.PMID:33535005 2015. BMC Cancer. 15: 627. PMID: 26353776P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. | Guarracino, JF., et al. 2016. Neuroscience. 326: 31-44. PMID: 27058149Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions. | Pugh, N., et al. 2017. Thromb Haemost. 117: 1588-1600. PMID: 28536721Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy. | Rwibasira Rudinga, G., et al. 2018. Int J Mol Sci. 19: PMID: 29443899The protease-activated receptor4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor4 desensitization, and is blocked by non-competitive P2Y12 inhibition. | Whitley, MJ., et al. 2018. J Thromb Haemost. 16: 2501-2514. PMID: 30347494The relation between ABO blood types and clinical and platelet function parameters in patients who underwent percutaneous coronary intervention. | Timur, AA., et al. 2019. Coron Artery Dis. 30: 51-58. PMID: 30407210Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid. | Brammer, JP. and Maguire, MH. 1984. Br J Pharmacol. 82: 61-72. PMID: 6428500The Relative Role of Soluble Guanylyl Cylase Dependent and Independent Pathways in Nitric Oxide Inhibition of Platelet Aggregation Under Flow | J. L. Sylman, S. M. Lantvit, M. M. Reynolds & Keith B. Neeves. 2014. Cellular and Molecular Bioengineering. 421–431.