Product Name :
SUPT16H Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
CDC68 antibody Chromatin specific transcription elongation factor 140 kDa subunit antibody Chromatin-specific transcription elongation factor 140 kDa subunit antibody Facilitates chromatin transcription complex subunit SPT16 antibody FACT 140 kDa subunit antibody FACT antibody FACT complex subunit SPT16 antibody FACTp140 antibody FLJ10857 antibody FLJ14010 antibody 展开
Function :
Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure.2,3-Dibromo-4-methylpyridine In stock It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of ‘Ser-392’ of p53/TP53 via its association withCK2 (casein kinase II). Also involved in vitamin D-coupledtranscription regulation via its association with the WINACcomplex, a chromatin-remodeling complex recruited by vitamin Dreceptor (VDR), which is required for the ligand-bound VDR-mediatedtransrepression of the CYP27B1 gene (By similarity).
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human SUPT16H/CDC68 601-700/1047
Species reactivity:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit
Verify application:
WB, ELISA, IHC-P, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.(S)-2-Fluoropropanoic acid Data Sheet Avoid repeated freeze/thaw cycles.PMID:33723798 The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
120 KDa
Positive control :
Ubiquitous.