Product Name :
RSPO2 Rabbit Polyclonal Antibody
Predicted band size :
28 kDa
Observed band size :
28 kDa
Synonyms:
RSPO2 UNQ9384/PRO34209 Roof plate-specific spondin-2 (hRspo2) R-spondin-2
Function :
R-spondin 2 also known as roof plate-specific spondin-2 is a secreted protein that in humans that is encoded by the RSPO2 gene. R-spondin 2 synergizes with canonical WNT to activate beta-catenin. RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway. In dogs, a variant on the Rspo2 gene is associated moustache and eyebrow thickness. In humans, recessive mutations in RSPO2 abrogate limb and lung development. Bruno Reversade and colleagues have reported in 2018 that loss of RSPO2 results in a syndrome of Tetra-amelia with lung agenesis.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within human RSPO2 aa 51-100 / 243.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3071540
Form :
Liquid
Concentration :
5.2300099-98-1 Formula 17ug/ul
Storage instructions:
Store at +4℃ after thawing.Silver acetate Price Aliquot store at -20℃.PMID:33649574 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 28 kDa
Positive control :
293 cell lysate, human lung tissue lysate, mouse brain tissue lysate, rat brain tissue lysate, human kidney tissue, mouse small intestine tissue.