Product Name :
Phospho-AMPK alpha 2 (S491) Recombinant Rabbit Monoclonal Antibody [JE59-49]
Predicted band size :
62 kDa
Observed band size :
62 kDa
Synonyms:
5′-AMP-activated protein kinase catalytic subunit alpha-2 antibody AAPK2_HUMAN antibody ACACA kinase antibody Acetyl CoA carboxylase kinase antibody Acetyl-CoA carboxylase kinase antibody AMPK alpha 2 chain antibody AMPK subunit alpha-2 antibody AMPK2 antibody AMPKa2 antibody AMPKalpha2 antibody 展开
Function :
5′-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene. The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol.368866-07-3 uses Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within
Species reactivity:
Human
Verify application:
WB
Coupling :
unconjugated
Clone number:
JE59-49
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.3-Fluoro-L-tyrosine Price Aliquot store at -20℃.PMID:33375773 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 62 kDa
Positive control :
HEK-293 cell lysate.